Callegaro et al reported 2 nomograms for predicting outcomes of a patient with a soft tissue sarcoma of an extremity. One nomogram predicts overall survival. The authors are from multiple institutions in Europe, the United States and Canada.
Patient selection: localized soft tissue sarcoma of an extremity
Parameters:
(1) age of the patient in years
(2) maximum diameter in cm
(3) histologic grade
(4) histologic type
points for age =
= (0.006384 * ((age)^2)) - (0.1572 * (age)) + 0.7649
points for diameter =
= (0.003681 * ((diam)^3)) - (0.259 * ((diam)^2)) + (7.42 * (diam)) + 0.5858
Parameter
Finding
Points
grade
Grade 1
0
Grade 2
29.4
Grade 3
43.5
type
myxoid liposarcoma
0
undifferentiated pleomorphic sarcoma (UPS)
7.1
dedifferentiated or pleomorphic liposarcoma
11.7
myxofibrosarcoma
14.9
MPNST
19
other
20.6
leiomyosarcoma
27.2
synovial sarcoma
29.6
vascular sarcoma
53
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 243.9
value of X =
= (-0.000002449 * ((score)^3)) + (0.0005768 * ((score)^2)) - (0.07523 * (score)) + 5.553
Total Score
10-Year Overall Survival
< 25.3
> 98%
25.3 to 188.1
1/ (1 + EXP((-1) * X))
> 188.1
< 1%
Performance:
• The area under the ROC curve is 0.77.
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