Andriulli et al evaluated the response of patients with viral hepatitis C (HCV) to therapy with peginterferon and ribavirin. A patient who clears the virus early is the best candidate to obtain viral eradication. The authors are from multiple institutions in Italy.
Patient selection: HCV type 1 treated with dual therapy (peginterferon and ribavirin)
Parameters:
(1) F4 hepatic fibrosis
(2) serum GGT
(3) baseline HCV RNA in 10^3 IU/mL
(4) IL28B genotype (CC, CT or TT)
(5) age in years
(6) rapid viral response
Parameter
Finding
Points
age
-0.02 * (age)
IL28B
CC
0
CT or TT
-1.22
serum GGT
normal
0
abnormal
-0.55
HCV RNA
-0.44 * LOG10(HCV RNA)
rapid viral response
no
0
yes
1.62
F4 hepatic fibrosis
no
0
yes
-0.80
rapid viral response and F4 hepatic fibrosis
no
0
yes
1.78
where:
• The handling of viral load is ambiguous (either absolute load or 10^3/mL). The absolute load is used in the implementation.
value of Y =
= SUM(points for all of the parameters) + 3.95
probability of sustained viral response =
= 1 / (1 + EXP((-1) *Y))
To read more or access our algorithms and calculators, please log in or register.
