Zhang et al reported a model for predicting axillary lymph node metastases in a woman with breast cancer in China. This can help guide patient management decision. The authors are from multiple institutions in China.
Patient selection: breast cancer in Chinese female from 20 to 90 years of age
Parameters:
(1) age in years
(2) size as T stage
(3) location in the breast
(4) invasion
(5) clinical lymph node status
(6) pathology
(7) molecular subtype
points for age =
= (-0.4914 * (age)) + 44.2286
Parameter
Finding
Points
size
T1
0
T2
7
T3
23
location
lower inner quadrant
0
upper inner quadrant
17
upper outer quadrant
31
lower outer quadrant
41
central
49
others
27
invasion
no
0
yes
26
lymph node
no
0
yes
42
pathology
DCIS with microinvasion
0
invasive ductal
100
invasive lobular
98
other
72
subtype
triple negative
0
HER2+
5
luminal-like
11
score =
= SUM(points for all 7 parameters)
Interpretation:
• minimum score: 0
• maximum score: 285.5
value of X =
= (0.029409 * (score)) - 5.2659
probability of axillary lymph node metastasis =
= 1 / (1 + EXP((-1) * (X)))
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