Tian et al reported prognostic factors for a patient with nasopharyngeal carcinoma and synchronous liver metastases. The authors are from Sun Yat-sen University Cancer Center in China.
Patient selection: nasopharyngeal carcinoma with synchronous liver metastases
Parameters:
(1) Karnofsky Performance Scale (KPS)
(2) serum LDH in U/L
(3) radiation therapy of the primary tumor
(4) cycles of chemotherapy
(5) response to chemotherapy
Parameter
Finding
Hazard Ratio
Karnofsky Performance
> 70
1
<= 70
2.2
serum LDH
< 245 U/L
1
>= 245 U/L
2.1
radiation therapy
no
2.9
yes
1
cycles chemotherapy
< 6
3.0
>= 6
1
response to chemotherapy
no
2.2
yes
1
cumulative product of hazard ratios impacting overall survival =
= PRODUCT(hazard ratios for all of the parameters)
Interpretation:
• minimum cumulative product: 1
• maximum cumulative product: 88.4
• The higher the product the worse the overall survival.
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