Willemsen et al reported a prediction model for tube feeding dependency for a patient undergoing chemoradiation for head and neck cancer. This can help to identify a patient who may require careful nutritional management. The authors are from multiple institutions in the Netherlands.
Patient selection: chemoradiation for head and neck cancer
Outcome: tube feeding dependency for >= 4 weeks
Parameters:
(1) percent change in pretreatment weight (a negative value in Table 1)
(2) texture of modified diet at baseline
(3) ECOG performance status
(4) tumor site
(5) N status
(6) mean RT dose to contralateral parotid gland in Gy
(7) mean RT dose to oral cavity in Gy
Parameter
Finding
Points
percent weight change
-0.038 * (percent)
texture of diet
not modified
0
reference
0.448
ECOG performance
0
0
1 to 4
0.674
tumor site
oral cavity, oropharynx, and hypopharynx
-0.793
other
0
N status
N0 or N1
0
N2 or N3
0.646
dose to parotid
0.027 * (Gy)
dose to oral cavity
0.022 * (Gy)
score =
= SUM(points for all of the parameters) - 1.419
probability of enteral tube dependency =
= 1 / (1 + EXP((-1) * (score))
Performance:
• The area under the ROC curve was 0.73 in the validation and 0.62 in validation cohorts.
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