van den Broek et al developed models for evaluating patients with advanced squamous cell carcinoma of the head and neck treated with intra-arterial chemoradiation. One model can be used to predict the probability of local control. The authors are from The Netherlands Cancer Institute, Academic Medical Hospital Amsterdam, and Antoni Van Leeuwenhoek Hospital in Amsterdam, The Netherlands.
Patient selection: T3 or T4 squamous cell carcinoma of oral cavity, oropharynx, hypopharynx or supraglottic larynx
Parameters:
(1) age in years
(2) tumor volume in mL
(3) primary site in oral cavity
(4) primary site in oropharynx
(5) N classification
(6) T classification
(7) intra-arterial infusion mode
|
Age in Years |
Points |
|
< 25 |
0 |
|
25 to 60 |
(0.2857 * (age in years)) – 7.143 |
|
61 to 80 |
(-0.1 * (age in years)) + 16 |
|
> 80 |
8 |
|
Volume |
Points |
|
< 50 mL |
(0.14 * (volume)) |
|
50 to 400 mL |
(0.2673 * (volume)) – 6.939 |
|
> 400 mL |
100 |
where:
• A volume of 50 mL indicates a tumor diameter of 4.6 cm.
• A tumor volume of 400 mL indicates a tumor diameter of 9.14 cm.
|
Parameter |
Finding |
Points |
|
site in oral cavity |
no |
2 |
|
|
yes |
0 |
|
site in oropharynx |
no |
8 |
|
|
yes |
0 |
|
N classification |
N0 or N1 |
7 |
|
|
N2 or N3 |
0 |
|
T classification |
T3 |
4 |
|
|
T4 |
0 |
|
intra-arterial infusion |
unilateral |
0 |
|
|
bilateral |
13 |
total score =
= SUM(points for all 7 parameters)
Interpretation:
• minimum score: 0
• maximum score around 150
• The higher the score the less the chances of achieving local control.
|
Total Score |
Probability of Local Control |
|
< 15 |
> 95% |
|
15 to 43 |
(-0.0971 * ((points)^2)) + (2.797 * (points)) + 74.07 |
|
> 43 |
< 17% |
Specialty: Hematology Oncology, Surgery, general, Otolaryngology
