van den Broek et al developed models for evaluating patients with advanced squamous cell carcinoma of the head and neck treated with intra-arterial chemoradiation. One model can be used to predict the probability of overall survival for 2 years. The authors are from The Netherlands Cancer Institute, Academic Medical Hospital Amsterdam, and Antoni Van Leeuwenhoek Hospital in Amsterdam, The Netherlands.
Patient selection: T3 or T4 squamous cell carcinoma of oral cavity, oropharynx, hypopharynx or supraglottic larynx
Parameters:
(1) age in years
(2) tumor volume in mL
(3) gender
(4) ASA score
(5) N classification
(6) lowest neck level involved
(7) T classification
(8) weight loss > 10%
|
Age in Years |
Points |
|
< 40 |
13 |
|
40 to 55 |
(-0.8666 * (age in years)) + 47.664 |
|
55 to 80 |
(0.24 * (age in years)) – 13.2 |
|
> 80 |
6 |
|
Volume |
Points |
|
0 to 400 |
(0.25 * (volume in mL)) - 0.5436 |
|
> 400 mL |
100 |
where:
• A volume of 50 mL indicates a tumor diameter of 4.6 cm.
• A tumor volume of 400 mL indicates a tumor diameter of 9.14 cm.
|
Parameter |
Finding |
Points |
|
gender |
female |
0 |
|
|
male |
15 |
|
ASA classification |
1 |
0 |
|
|
2 or 3 |
23 |
|
N classification |
N0 or N1 |
0 |
|
|
N2 or N3 |
8 |
|
lowest neck level |
none or II or III |
0 |
|
|
IV |
28 |
|
T classification |
T3 |
8 |
|
|
T4 |
0 |
|
weight loss > 10% |
no |
0 |
|
|
yes |
18 |
total score =
= SUM(points for all 7 parameters)
Interpretation:
• minimum score: 0
• maximum score around 200
• The higher the score the less the chances of surviving 2 years.
|
Total Score |
Probability of Local Control |
|
< 15 |
> 88% |
|
15 to 70 |
(-0.01196 * ((points)^2)) – (0.1745 * (points)) + 93.83 |
|
> 70 |
< 24% |
Specialty: Hematology Oncology, Surgery, general, Otolaryngology
