Model of Tham et al for Determining the Daily Dose of Warfarin to Give to an Asian Based on Genotypic Analysis of Vitamin K Eposoxide Reductase Complex and Cytochrome P450 2C9


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The daily dose of warfarin varies widely in Asians due to variations in its metabolism between the difference ethnic groups. Tham et al derived a model that can predict the warfarin dose based on genotypic analysis of the patient. The authors are from National University Hospital (Singapore), Oncology Research Institute (Singapore) and Ordway Research Institute (Albany, New York).

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