Model of Satwani et al for a Young Patient with Hodgkin's Disease Undergoing Autologous Hematopoietic Stem Cell Transplant (AutoHCT)

Description

Satwani et al reported a model for evaluating a young patient with Hodgkin's disease undergoing autologous hematopoietic stem cell transplant (autoHCT). This can help to identify a patient who may require more aggressive management. The authors are from multiple institutions from around the world.

Patient selection: pediatric patient or young adult with relapsed or refractory Hodgkin's disease

Outcome: progression-free survival (PFS)

Parameters:

(1) Karnofsky performance status

(2) time from diagnosis to first relapse (TDFR) in years

(3) extranodal involvement at the time of autoHCT

(4) disease chemoresistant at time of autoHCT

Parameter	Finding	Points
Karnofsky performance	>= 90%	0
	< 90%	1
TDFR	< 1 year	1
	>= 1 year	0
extranodal involvement	no	0
	yes	1
chemoresistance	no	0
	yes	1

total score =

= SUM(points for all 4 parameters)

Interpretation:

• minimum score: 0

• maximum score: 4

• The higher the score the greater the risk.

Total Score	Risk Group	5-Year Progression Free Survival
0	low	72%
1 or 2	intermediate	53%
3 or 4	high	23%

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Model of Satwani et al for a Young Patient with Hodgkin's Disease Undergoing Autologous Hematopoietic Stem Cell Transplant (AutoHCT)

Description

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