Santini et al reported a model for predicting the response of a patient with low or intermediate-1 risk myelodysplasia to erythropoietin. The authors are from multiple institutions in Italy, France and Germany.
Patient selection: low or intermediate-1 risk myelodysplasia by the classical IPSS
Parameters:
(1) serum erythropoietin in mU/mL
(2) serum ferritin in ng/mL
(3) IPSS-R
Parameter
Finding
Points
serum erythropoietin
<= 200 mU/mL
0
> 200 mU/mL
1
serum ferritin
<= 350 ng/mL
0
> 350 ng/mL
1
IPSS-R
very low
0
low
1
intermediate
2
high
3
total score =
= SUM(points for all 3 parameters)
Interpretation:
• minimum score: 0
• maximum score: 5 (4 stated in article, but this may be maximum seen in the study group)
Score
Response to Erythropoietin
0
85%
1
80%
2
64%
3
40%
4
20%
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