Ray-Coquard et al developed model for identifying adults with cancer who required blood transfusion following chemotherapy. The authors are members of the ELYPSE 1 Study Group from Lyon, Villejuif, Chambery, Neuilly and Toulouse, France.
Patient selection: age >= 18 years of age, solid tumor and receiving chemotherapy
Endpoint: Severe anemia requiring blood transfusion within 31 days of chemotherapy
Parameters at start of chemotherapy:
(1) ECOG performance scale
(2) hemoglobin
(3) absolute lymphocyte count
Parameter
Finding
Points
ECOG performance scale
0 or 1
0
2, 3 or 4
1
hemoglobin
>= 12 g/dL
0
< 12 g/dL
3
absolute lymphocyte count (ALC)
> 700 per µL
0
<= 700 per µL
1
total risk score =
= SUM(points for all 3 parameters)
Interpretation:
• minimum risk score: 0
• maximum risk score: 3
Number of Risk Factors
Percent Requiring RBC Transfusion
0
1.2%
1
3.8%
2 or 3
11%
4 or 5
30%
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