Polilli evaluated patients for sepsis in the intensive care unit. They used the monocyte distribution width and serum procalcitonin to determine the risk of sepsis. The authors are from Pescara General Hospital, University Chieti and University of Bologna in Italy.
Patient selection: patient in the ICU
Parameters:
(1) monocyte distribution width (MDW)
(2) procalcitonin in ng/mL
MDW
Procalcitonin
Diagnosis
<= 20
NA
sepsis ruled out
20.01 to 22
> 0.5 ng/mL
moderate risk for sepsis
20.01 to 22
<= 0.5 ng/mL
? low risk for sepsis
22.01 to 23
> 0.5 ng/mL
high risk for sepsis
22.01 to 23
<= 0.5 ng/mL
? moderate risk for sepsis
> 23
> 0.5 ng/mL
sepsis ruled in
> 23
<= 0.5 ng/mL
very high risk for sepsis
Performance:
• The area under the ROC curve for MDW was 0.84.
• The area under the ROC curve for procalcitonin was 0.81.
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