Mearelli et al reported a model for predicting sepsis in a patient presenting to the Emergency Department. Certain serum biomarkers can help to identify a patient with sepsis. The authors are from the University of Trieste, Eastern Piedmont University, University of Brescia, University "Sapienza" of Rome, General Hospital of Susa and the University of Turin.
Patient selection: Emergency Department with SIRS
The patient is initially evaluated using the nomogram of Mearelli as described in the same paper.
Serum biomarkers:
(1) sPLA2GIIA (soluble phospholipase A2 Group IIA) in ng/mL
(2) procalcitonin in ng/mL
Parameters:
(1) probability of sepsis according to nomogram
(2) serum sPLA2GIIA
(3) serum procalcitonin
Nomogram
sPLA2GIIA
Procalcitonin
Infection
low risk
< 11.25 ng/mL
NA
unlikely
low risk
>= 11.25 ng/mL
NA
likely
intermediate risk
< 25.39 ng/mL
< 0.1787
unlikely
intermediate risk
>= 25.39 ng/mL
NA
likely
intermediate risk
NA
>= 0.1787
likely
high risk
NA
NA
likely
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