Description

Lee et al developed a model for predicting atherosclerotic disease involving the left main coronary artery based on clinical and exercise test findings. This can help identify patients who may benefit from additional testing. The authors are from Brigham and Women's Hospital and Harvard Medical School in Boston.


 

Parameters used in logistic regression model:

(1) age of the patient in years

(2) typical anginal symptoms

(3) prevalence of left main coronary artery disease in the general population

(4) ST segment depression during exercise testing

 

Parameter

Finding

Points

typical anginal symptoms

absent

-0.611

 

present

+0.455

ST segment depression

< 1 mm

-1.406

 

1.0 - 1.9 mm

-0.887

 

2.0 - 2.9 mm

+0.632

 

>= 3.0 mm

+1.097

 

X =

= (0.057 * ((age in years) - 65)) + (points for typical anginal symptoms) + (points for ST segment depression during exercise testing) + LN((local prevalence of left main coronary artery disease) / (1 - (local prevalence of left main coronary artery disease)))

 

probability of left main coronary artery disease in the patient =

= EXP(X) / (1 + EXP(X))

 

where:

• Based on the example in the Appendix, "log" is interpreted as natural logarithm.

• The probability equation above is a rearrangement for the equation:

LN((probability) / (1 - (probability)))

• Patients with no angina or atypical anginal pain appear to be lumped together.

 


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