Kohrt et al developed several models for predicting the risk of nonsentinel lymph node (NSLN)involvement in a woman with breast cancer and positive sentinel lymph nodes. The authors are from Stanford University.
NOTE: A risk calculator by the authors is available at
www-stat.stanford.edu/~olshen/NSLNcalculator/
Parameters for the RP-ROC model:
(1) lymphovascular invasion (LVI) in breat tumor
(2) tumor diameter in cm
(3) macrometastasis in a sentinel lymph node (MM)
(4) isolated tumor cells or clusters (ITC)
|
Metastasis in Sentinel Lymph Node |
Size in mm |
|
isolated tumor cells or clusters |
<= 0.20 mm |
|
micrometastasis |
0.21 to 2.0 mm |
|
macrometastasis |
> 2.0 mm |
|
LVI |
tumor size |
ITC |
MM |
Percent NSLN with Mets |
|
yes |
NA |
ITC only |
NA |
6% |
|
yes |
< 1.3 cm |
more than ITC |
NA |
38% |
|
yes |
>= 1.3 cm |
more than ITC |
NA |
93% |
|
no |
< 2.8 cm |
NA |
present |
33% |
|
no |
< 2.8 cm |
NA |
absent |
10% |
|
no |
>= 2.8 cm |
NA |
NA |
42% |
|
Risk of Lymph Node Involvement |
Risk Level |
|
<= 10% |
low |
|
30 to 45% |
moderate |
|
60% |
high |
|
> 90% |
very high |
Specialty: Hematology Oncology, Surgery, general, Obstetrics & Gynecology
