Description

Iliuta et al used kinetic models to determine the duration of hemodialysis sessions for the treatment of acute ethylene glycol poisoning. The authors are from Universite Laval, University of Montreal and CHU de Quebec Research Center in Canada.


Molecular weight of ethylene glycol: 62.07

1 mmol/L = 6.2 mg/dL

 

Dialysis settings:

(1) blood flow > 300 mL per minute

(2) dialysate flow 500-800 mL per minute

(3) membrane surface area > 2 square meters

 

Target serum level: 2 mmol/L or less

 

Metabolic acidosis must be corrected for estimates to be valid.

 

Parameters:

(1) initial ethylene glycol concentration in mmol/L

 

duration of hemodialysis in hours =

= 4.7 * (LN((initial ethylene glycol concentration in mmol/L) / 2)

 

Using the nomogram in Figure 5 using 90th percentile half-life (195 minutes):

 

hours of hemodialysis =

= (4.7517 * LN(initial ethylene glycol concentration in mmol/L)) - 3.4227


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