Model of Dorajoo et al for Survival Following Primary Tumor Resection in Stage IV Colorectal Cancer with Unresectable Metastases

Description

Dorajoo et al reported a score for predicting survival for a patient with stage IV colorectal cancer and unresectable metastases. This can help to identify a patient who may benefit from more aggressive management or novel therapy. The authors are from National University of Singapore and Singapore General Hospital.

Patient selection: Stage IV colorectal cancer with unresectable metastases, status post resection primary tumor

Parameters:

(1) age in years

(2) serum albumin in g/L

(3) serum CEA concentration in ng/mL

(4) metastatic sites (liver, lung, bone, carcinomatosis)

(5) tumor grade

Parameter	Finding	Points
age	< 65 years	0
	>= 65 years	1
serum albumin	>= 35 g/L	0
	< 35 g/L	1
CEA	< 250 ng/mL	0
	>= 250 ng/mL	2
liver metastases	no	0
	yes	2
lung metastases	no	0
	yes	1
bone metastases	no	0
	yes	2
carcinomatosis	no	0
	yes	2
tumor grade	well-differentiated	0
	moderately differentiated	1
	poorly differentiated	3
	undifferentiated	3

total score =

= SUM(points for all of the parameters)

Interpretation:

• minimum score: 0

• maximum score: 14

• The higher the score the worse the survival.

Total Score	Survival	24 Month Survival
0 to 3	good	33%
4 to 6	moderate	17%
7 to 14	poor	3%

Performance:

• The area under the ROC curve was 0.75 for 6 month survival and 0.7 for 24 month survival

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Model of Dorajoo et al for Survival Following Primary Tumor Resection in Stage IV Colorectal Cancer with Unresectable Metastases

Description

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