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Model of Delobel et al for Rectal Toxicity Following Radiotherapy for Prostate Cancer

Description

Delobel et al developed a nomogram for predicting the risk of radiation proctitis following radiation therapy of prostate cancer. The authors are from multiple institutions in France, Universidad Nacional de Columbia and Southeast UniversityNanjing.


Patient selection: radiation therapy for prostate cancer

 

Outcome: radiation proctitis (bleeding, urgency, diarrhea, incontinence), Grade >= 2

 

Parameters:

(1) radiation therapy technique (3DCRT or 3D confocal; IMRT or intensity-modulated; IGRT or image-guided)

(2) total radiation dose in Gray (Gy), from 70 to 80 Gy

(3) dose fractionations ( 2 vs 2.5 Gy)

 

points for total dose over range 70 to 80 Gy =

= (6.3297 * (dose)) - 442.97

 

Parameter

Finding

Points

radiation technique

3DCRT

100

 

IMRT

80

 

IGRT + IMRT

0

dose fraction

2.0 Gy

0

 

2.5

34.4

 

total score =

= SUM(points for all 3 parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 197.6

• The higher the score the greater the risk of rectal toxicity

 

Score

Points

< 22.1

< 4%

22.1 to 174.9

(0.00055813 * ((score)^2)) + (0.0070185 * (score)) + 3.6885

>= 175

> 22%

 


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