Description

Buettner et al developed a model for predicting one-year mortality following complex gastrointestinal surgery for a malignancy. This model uses sarcopenia as a surrogate marker for farilty. The authors are from the Johns Hopkins Hospital.


 

Patient selection: GI surgery (hepatobiliary, pancreatic, colorectal)

 

Outcome: 1-year mortality

 

Parameters:

(1) age in years

(2) preoperative hemoglobin in g/dL

(3) ECOG performance status

(4) sarcopenia (based on total psoas muscle density by Hounsfield unit average calculation, HUAC. Sarcopenia for males < 39.9 HU and for females < 38.1)

 

Parameter

Findings

Points

age in years

<= 55 years

0

 

56 to 65 years

2.5

 

66 to 75 years

5.8

 

>= 76 years

10

preoperative hemoglobin

>= 12.5 g/dL

0

 

< 12.5 g/dL

5.1

ECOG

0

0

 

1 to 4

3.6

sarcopenia

Absent

0

 

present

6.7

 

total score =

= SUM(points for all 4 parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 25.4

• The higher the score the greater the 1-year mortality rate.

 

percent mortality at 1-year =

= (0.0647 * ((score)^2)) - (0.2595 * (score)) + 5.575

 

Performance:

• The area under the ROC curve was 0.70.

 


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