Barr Fritcher et al evaluated patients with pancreatobiliary strictures using several clinical and laboratory findings. The authors are from the Mayo Clinic.
Parameters:
(1) cytology diagnosis
(2) FISH findings
(3) age in years
(4) primary sclerosing cholangitis
The probability of malignancy was very high if one or both of the following is present:
(1) malignant cytology
(2) polysomy on FISH (>=3 signals for >= 2 probes, odds ratio 77.7)
If neither of these parameters were met, then the cumulative odds ratios can be calculated based on the multivariate model..
Parameter |
Finding |
Odds Ratio |
---|---|---|
FISH |
trisomy |
1.76 |
|
other |
1 |
age in years |
|
(1.02)^(age) |
PSC |
absent |
1 |
|
present |
0.43 |
cytology findings |
suspicious |
6.02 |
|
other |
1 |
cumulative odds ratio =
= PRODUCT(odds ratio for the 4 parameters)
Purpose: To evaluate a patient with a pancreatobiliary stricture using the model of Barr Fritcher et al.
Specialty: Hematology Oncology, Surgery, general, Gastroenterology
Objective: risk factors, clinical diagnosis, including family history for genetics
ICD-10: C22.1, C24, C25,