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Model of Allison et al for Estimating Carbamazepine 10,11- Epoxide Concentration in Serum Based on Carbamazepine Levels by 2 Different Immunoassays

Specialty:

Clinical Pharmacology & Toxicology
Emergency Medicine & Critical Care
Emergency Medicine & Critical Care
Neurology, Psychiatry, Ophthalmology & Otolaryngology

Objective:

ICD-10:

Description:

Allison et al developed 2 equations that can be used to predict the serum concentration of carbamazepine 10,11-epoxide in a patient being treated with carbamazepine. These are based on cross-reactivity of both chemicals in 2 different types of immunoassays. This allows for measuring the 10,11-epoxide concentration without need for HPLC or other type of chromatography. The authors are from the University of Texas in Houston and ARUP Laboratories in Salt Lake City.

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