The mitotic karyorrhexis index (MKI) is the percentage of cells showing mitotic activity or nuclear karyorrhexis.
Magnification for count: 400x
Number of cells counted: 5,000; 10 high powered fields counted on each of 4 sections from the tumor, with the maximum count used for grading
Counting (Joshi, 1992):
(1) count in most mitotically active area
(2) features of mitosis: absent nuclear membrane, presence of hairy or spiky projections, and basophilic or clear cytoplasm
(3) features of karyorrhectic cells: condensed punctate or lobular nuclear material with eosinophilic cytoplasm
count =
= (number of cells showing mitosis) + (number of karyorrhectic cells)
MKI
Risk Group (Shimada)
< 2% (< 100 in 5,000)
low
2-4% (100 to 200)
intermediate
> 4% (> 200 in 5,000)
high
Risk Group (Klijanienko)
<= 2% (< 100 in 5,000)
1
3-4% (150 to 200)
2
3
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Specialty: Hematology Oncology
