Antisynthetase syndrome (anti-Jo-1 syndrome) may be misdiagnosed as rheumatoid arthritis, especially early in its course.
The classic triad for antisynthetase syndrome:
(1) polyarthritis
(2) myositis
(3) interstitial lung disease
Most patients present without the complete triad, often with arthritis alone and with positive rheumatoid factor.
Misdiagnosis can be avoided by:
(1) testing for antisynthetase antibodies (anti-Jo-1, anti-Ro-52, anti-PL-7, anti-PL-12)
(2) diagnostic review with appearance of myositis, interstitial lung disease, Raynaud's phenomenon, skin rash or mechanic's hands
To read more or access our algorithms and calculators, please log in or register.
Specialty: Immunology/Rheumatology
