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Description

Leptospirosis and hantavirus infection can be difficult to tell apart. Kaya et al reported the MICE score to help to identify a patient with leptospirosis. The authors are from Karadeniz Technical University in Turkey.


Parameters:

(1) WBC count per microliter

(2) serum total bilirubin in mg/dL

(3) serum CRP in mg/dL

(4) serum creatinine in mg/dL

(5) serum CK in U/L

 

Parameter

Finding

Points

WBC count

<= 7,500 per µL

0

 

7,501 to 15,000 per µL

1

 

> 15,000 per µL

2

serum total bilirubin

<=3 mg/dL

0

 

3.1 to 10 mg/dL

1

 

> 10 mg/dL

2

serum CRP

<= 5

0

 

5.01 to 15

1

 

> 15

2

serum creatinine

<= 1.5 mg/dL

0

 

1.6 to 3 mg/dL

1

 

> 3 mg/dL

2

serum CK

<= 500 U/L

0

 

501 to 1,000 U/L

1

 

> 1,000 U/L

2

 

total score =

= SUM(points for all of the parameter)

 

Interpretation:

• minimum score: 0

• maximum score: 10

• The higher the score the more likely that the patient has leptospirosis.

• A MICE score >= 3 has a sensitivity of 0.935 and specificity of 0.929.

 

Performance:

• The area under the ROC curve is 0.96.


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