Leptospirosis and hantavirus infection can be difficult to tell apart. Kaya et al reported the MICE score to help to identify a patient with leptospirosis. The authors are from Karadeniz Technical University in Turkey.
Parameters:
(1) WBC count per microliter
(2) serum total bilirubin in mg/dL
(3) serum CRP in mg/dL
(4) serum creatinine in mg/dL
(5) serum CK in U/L
Parameter
Finding
Points
WBC count
<= 7,500 per µL
0
7,501 to 15,000 per µL
1
> 15,000 per µL
2
serum total bilirubin
<=3 mg/dL
0
3.1 to 10 mg/dL
1
> 10 mg/dL
2
serum CRP
<= 5
0
5.01 to 15
1
> 15
2
serum creatinine
<= 1.5 mg/dL
0
1.6 to 3 mg/dL
1
> 3 mg/dL
2
serum CK
<= 500 U/L
0
501 to 1,000 U/L
1
> 1,000 U/L
2
total score =
= SUM(points for all of the parameter)
Interpretation:
• minimum score: 0
• maximum score: 10
• The higher the score the more likely that the patient has leptospirosis.
• A MICE score >= 3 has a sensitivity of 0.935 and specificity of 0.929.
Performance:
• The area under the ROC curve is 0.96.
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