Methods to Detect Thawing of a Frozen Solution

Description

Some frozen solutions may deteriorate if thawed and left unfrozen for any length of time. A solution that has thawed needs to be evaluated for potency and safety before it can be used. Certain techniques can be used to detect if a frozen solution has thawed.

A solution may be frozen in:

(1) a solid (glass, plastic) container (tube, bottle)

(2) a flexible plastic bag

Frozen Solution in a Bottle or Tube	What You See if Solution Thaws
freeze at a slant (45 degrees) and store vertical	horizontal surface
freeze on side with sterile glass beads	glass beads will be in bottom of container

where:

• If frozen at an angle mark the surface of the fluid with a marking pen.

Frozen Solution in a Flexible Bag	What You See if Solution Thaws
indent with tube or band while freezing	indent disappears
freeze on side with a few bubbles, and store vertical	bubbles will no longer be on the side

There are other ways to detect thawing:

(1) monitored refrigerator with data storage

(2) thermometer that records a maximum temperature

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Description

Specialty

ICD-10