Loos et al have proposed a method for fixed dosing of cisplatin. This could reduce errors in dosing, especially in persons with a body surface area that is low or high. The authors are from Erasmus Medical Center in Rotterdam, the Netherlands.
Parameters:
(1) body surface area in square meters
(2) dose of cisplatin based on body surface area
|
Body Surface Area Cluster |
Recommended BSA to Use in Fixed Dosage Calculation |
|
<= 1.65 square meter |
1.57 |
|
1.66 to 2.04 square meter |
1.86 |
|
>= 2.05 square meter |
2.17 |
Fixed Dose for Low BSA Cluster
|
BSA-based Dose |
Fixed Dose Cisplatin |
|
50 mg per square meter |
80 mg |
|
60 mg per square meter |
95 mg |
|
70 mg per square meter |
110 mg |
|
75 mg per square meter |
120 mg |
|
80 mg per square meter |
125 mg |
|
100 mg per square meter |
155 mg |
Fixed Dose for Intermediate BSA Cluster
|
BSA-based Dose |
Fixed Dose Cisplatin |
|
50 mg per square meter |
95 mg |
|
60 mg per square meter |
110 mg |
|
70 mg per square meter |
130 mg |
|
75 mg per square meter |
140 mg |
|
80 mg per square meter |
150 mg |
|
100 mg per square meter |
185 mg |
Fixed Dose for High BSA Cluster
|
BSA-based Dose |
Fixed Dose Cisplatin |
|
50 mg per square meter |
110 mg |
|
60 mg per square meter |
130 mg |
|
70 mg per square meter |
150 mg |
|
75 mg per square meter |
165 mg |
|
80 mg per square meter |
175 mg |
|
100 mg per square meter |
215 mg |
Specialty: Hematology Oncology, Surgery, general
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