Parameters:
(1) area under the dosage curve (AUC) for carboplatin in mg•min/mL following an intravenous infusion
(2) glomerular filtrate rate (GFR)
dose of carboplatin in mg for single agent therapy =
= (target AUC) * ((1.2 * (GFR)) + 20)
This was refined to:
dose of carboplatin in mg for single agent therapy =
= (target AUC) * ((GFR) + 25)
where:
• AUC is determined by measured plasma concentrations over time following an intravenous dose, plotted as mg/mL versus time after dose in minutes.
• The target AUC was 5 mg•min/mL for single agent therapy in a previously treated adult.
• The target AUC was 7 mg•min/mL for single agent therapy in an adult not previously treated.
• GFR was reported in mL per minute rather than mL per minute per 1.73 square meter.
• The maximum GFR to use should be 125 mL/min. Use of a higher value can result in an excessive and potentially toxic dose.
