Parameters:
(1) eGFR in mL per min
(2) number of drugs being taken
(3) number of drugs causing low risk of harm, up to 3
(4) number of drugs causing medium risk of harm, up to 8
(5) number of drugs causing high risk harm, up to 7
(6) number of low or medium risk drug interactions, up to 12
(7) number of high-risk drug interactions, up to 2
|
Parameter |
Finding |
Points |
|
eGFR |
>= 60 |
0 |
|
|
30.01 to 59.99 |
5 |
|
|
<= 30 |
10.6 |
|
number of drugs |
0 to 5 |
0 |
|
|
6 to 11 |
5 |
|
|
>= 12 |
10.6 |
|
low risk drugs |
|
0.25*MIN(3, |
|
medium risk drugs |
|
0.5*MIN(8, |
|
high risk drugs |
|
MIN(7, |
|
low-medium risk interactions |
|
0.25*MIN(12, |
|
high risk interactions |
|
0.5*MIN(2, |
where:
• The sum of low, medium and high-risk drugs should not exceed the total number of drugs.
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: dependent on number and types of drugs, probably around 37
• A cut-off of > 15 has the highest Youden index (sensitivity 0.52, specificity 0.81).
Performance:
• The area under the ROC curve is 0.70 according to Hoi et al. Better performance is seen in other populations.
