Medicines Comorbidity Index (MCI) of Narayan and Nishtala

Condition

Points

cancer

3

HIV/AIDS

3

diabetes

2

end-stage renal disease

2

epilepsy

2

respiratory illness

2

dementia

1

dyslipidemia

1

glaucoma

1

gout

1

heart disease

1

hepatitis B

1

hepatitis C

1

hypertension

1

hepatic cirrhosis

1

osteoporosis

1

Parkinson's disease

1

peptic ulcer

1

rheumatoid arthritis

1

thyroid disorder

1

Condition

Drugs

cancer

alkylating agents, anthracyclines, anti-androgens, anti-lymphocyte monoclonal antibodies, antimetabolites, aromatase inhibitors, gonadotropin-releasing hormone agonists, other cytotoxic and non-cytotoxic antineoplastics, platinum compounds, selective estrogen receptor modulators, taxanes, thalidomide analogues, topoisomerase I inhibitors, tyrosine kinase inhibitors, Vinca alkaloids

HIV/AIDS

HIV-protease inhibitors, integrase inhibitors, nucleoside reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, other antiretrovirals

diabetes

acarbose, biguanides, insulins, sulfonylureas, thiazolidinediones

end-stage renal disease

calcium polystyrene sulfonate, epoetin alfa, epoetin beta, polystyrene sulfonate sodium

epilepsy

barbiturates, benzodiazepines, carbamazepine, ethosuximide, gabapentin, lacosamide, lamotrigine, levetiracetam, oxcarbazepine, phenytoin, pregabalin, sulthiame, topiramate, valproate, vigabatrin

respiratory illness

antimuscarinic bronchodilators, beta-2 agonists, cromone, inhaled corticosteroids, leukotriene receptor antagonists, xanthines

dementia

anticholinesterase

dyslipidemia

bile acid-binding resins, fibrates, other drugs for dyslipidemia, statins

glaucoma

acetazolamide, alpha2 agonists, beta blockers (ophthalmic), carbonic anhydrase inhibitors,

mannitol, pilocarpine, prostaglandin analogues

gout

colchicine, probenecid, xanthine oxidase inhibitor

heart disease

aldosterone antagonists, angiotensin-converting enzyme inhibitors, antiplatelets agents, anticoagulation, beta blockers, calcium channel blockers, loop diuretics, nicorandil, nitrates, perhexilline

hepatitis B

adefovir, entecavir, peginterferon alfa

hepatitis C

HCV protease inhibitors, ribavirin, ribavirin with peginterferone alfa

hypertension

clonidine, diazoxide, hydralazine, methyldopa, minoxidil, potassium-sparing diuretic, sartans, selective alpha blockers, sodium nitroprusside, thiazide and related diuretics

hepatic cirrhosis

lactulose (> 30 mL per day), spironolactone (> 50 mg/day)

osteoporosis

bisphosphonates, calcitonin, teriparatide, vitamin D

Parkinson's disease

amantadine, anticholinergics, dopamine agonists, entacapone, levodopa with benserazide or carbidopa, monoamine oxidase type B inhibitors

peptic ulcer

antacids, bismuth subcitrate, H2 antagonists, misoprostol, proton pump inhibitors, sucralfate

rheumatoid arthritis

auranofin, hydroxychloroquine, immunosuppressants, penicillamine, sodium aurothiomalate, sulphasalazine, TNF-alpha antagonists

thyroid disorder

antithyroid drugs, thyroid hormone