A patient with baroreflex failure should avoid certain drugs and foods since they may cause or worsen an episode.


Mechanism: elevation of norepinephrine concentration at synapses


Drugs of abuse:

(1) cocaine

(2) amphetamines

(3) other stimulant drugs



(1) tricyclic antidepressants (blocks the norepinephrine transporter)

(2) monoamine oxidase A inhibitors (MAOI)


Selective serotonin release inhibitors (SSRI) may be a safer alternative if an antidepressant is indicated.



(1) yohimbine (unless being used to treat an episode of hypotension)



(1) tyramine-rich food or beverages

(2) prednisone


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