Median rhomboid glossitis is a rare form of chronic inflammation affecting the tongue.


Synonym: chronic candidiasis, central papillary atrophy


Clinical findings:

(1) The tongue shows a midline rhomboid-shaped plaque anterior to the foramen cecum that may range from red to red-white in color.

(2) A biopsy of the area may show atrophy of filiform papillae and chronic inflammation, often with yeast forms. Areas of hyperkeratosis may be present.

(3) A patient may experience a burning sensation when eating certain foods.


Risk factors:

(1) male gender

(2) chronic candidiasis

(3) immunosuppression


The presence median rhomboid glossitis and chronic inflammation of the hard plaate may be seen in patients infected with HIV.


Differential diagnosis:

(1) cancer of the tongue

(2) leukoplakia


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