Possible basis: Newly-released platelets are larger, so increased release raises the MPV. Lymphopenia can occur due to chemotherapy, malnutrition and other causes.
Parameters:
(1) mean platelet volume (MPV), normal range may vary (9.4 to 12.3 fL; 7.2 to 11.7 fL, other)
(2) absolute lymphocyte count in 10^3 per microliter
MPV to lymphocyte ratio =
= (mean platelet volume in femtoliters) / (absolute lymphocyte count)
Interpretation:
• A ratio >=4.42 can be seen in acute appendicitis and >= 8.08 in perforated appendicitis (Bozlu et al), with a normal range 3.69 +/- 2.33.
• A ratio >= 3.61 is associated with higher mortality in non-metastatic renal cell carcinoma (Zyczkowski et al).
• Trending the ratio over time may be able to detect an increase from baseline.
