Patient selection: perihilar cholangiocarcinoma
Criteria for Stage IV - one or both of the following:
(1) peritoneal metastases
(2) ECOG performance status 3 or 4
Criteria for Stage III - one or more of the following:
(1) serum CA 19-9 >= 1,000 U/mL
(2) lymph node metastases
(3) multiple tumors
(4) tumor size > 3 cm
Criteria for Stage II - one or both of the following:
(1) ECOG status 1 or 2
(2) vascular encasement
Criteria for Stage I - none of the above and all of the following:
(1) ECOG 0
(2) tumor size <= 3 cm
(3) single tumor
(4) no metastases or vascular encasement
(5) serum CA 19-9 < 1,000 U/mL
|
Stage
|
Median Survival
|
Hazard Ratio
|
|
I
|
48.6 months
|
1
|
|
II
|
21.8 months
|
1.7
|
|
III
|
8.6 months
|
3.1
|
|
IV
|
2.8 months
|
8.7
|
