Bellane-Chantelot et al listed criteria for recognizing a patient with maturity-onset diabetes of the young associated with anomalies of HNF1A (MODY3). These can help to differentiate MODY 3 from early-onset diabetes 2. The authors are from multiple hospitals in France.


Gene affected: hepatocyte nuclear factor-1alpha (HNF1A)


Inheritance: autosomal dominant


Reasons to suspect MODY3:

(1) age of the patient at onset < 25 years (although an older age does not exclude the diagnosis)

(2) number of affected generations with diabetes >= 3

(3) lower BMI AND absence of diabetic symptoms

(4) Euro-Caucasian descent



(1) autoimmune diabetes

(2) insulin-dependent diabetes


Definitive diagnosis involves assessment of the HNF1A gene.


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