Vanier et al reported a matrix for prediction of early radiographic progression of early rheumatoid arthritis (RA). This can help to identify a patient who may benefit from more aggressive management. The authors are from multiple institutions in Europe.
Patient selection: early rheumatoid arthritis
Outcome: rapid radiographic progression (RRP) at 1 year
Parameters:
(1) rheumatoid factor (RF), positive or negative
(2) rheumatoid joint erosions seen
(3) serum CRP in mg/L
(4) swollen joint count (SJC), out of 28 joints
|
RF and Erosions |
CRP |
SJC |
Probability |
|
pos, no erosions |
< 10 |
< 6 |
0.11 |
|
|
|
6 to 10 |
0.11 |
|
|
|
> 10 |
0.15 |
|
|
10 to 30 |
< 6 |
0.13 |
|
|
|
6 to 10 |
0.13 |
|
|
|
> 10 |
0.18 |
|
|
> 30 |
< 6 |
0.21 |
|
|
|
6 to 10 |
0.21 |
|
|
|
> 10 |
0.28 |
|
positive, erosions |
< 10 |
< 6 |
0.22 |
|
|
|
6 to 10 |
0.22 |
|
|
|
> 10 |
0.29 |
|
|
10 to 30 |
< 6 |
0.25 |
|
|
|
6 to 10 |
0.25 |
|
|
|
> 10 |
0.33 |
|
|
> 30 |
< 6 |
0.37 |
|
|
|
6 to 10 |
0.38 |
|
|
|
> 10 |
0.47 |
|
neg, no erosions |
< 10 |
< 6 |
0.05 |
|
|
|
6 to 10 |
0.06 |
|
|
|
> 10 |
0.08 |
|
|
10 to 30 |
< 6 |
0.06 |
|
|
|
6 to 10 |
0.07 |
|
|
|
> 10 |
0.09 |
|
|
> 30 |
< 6 |
0.11 |
|
|
|
6 to 10 |
0.11 |
|
|
|
> 10 |
0.15 |
|
negative, erosions |
< 10 |
< 6 |
0.11 |
|
|
|
6 to 10 |
0.12 |
|
|
|
> 10 |
0.16 |
|
|
10 to 30 |
< 6 |
0.13 |
|
|
|
6 to 10 |
0.14 |
|
|
|
> 10 |
0.18 |
|
|
> 30 |
< 6 |
0.22 |
|
|
|
6 to 10 |
0.22 |
|
|
|
> 10 |
0.29 |
|
Probability |
Risk |
|
< 0.10 |
very low |
|
0.10 - 0.19 |
low |
|
0.20 to 0.35 |
intermediate |
|
> 0.35 |
high |
Specialty: Immunology/Rheumatology
