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Maternal HELLP Syndrome or Acute Fatty Liver of Pregnancy (AFLP) Secondary to an Inherited Metabolic Disorder in the Fetus

Description

A mother who develops hemolysis, elevated liver enzymes, low platelets (HELLP) or acute fatty liver of pregnancy (AFLP) during pregnancy may have a fetus with an inherited metabolic disorder.


Inherited Disorder in Fetus

HELLP

AFLP

carnitine palmitoyltransferase I (CPT I) deficiency

 

AFLP

medium-chain acyl -CoA dehydrogenase (MCAD) deficiency

HELLP

 

long-chain-3-hydroxyacyl-coenzyme A dehydrogenase (LCHAD) deficiency

HELLP

AFLP

 

The fetus of a mother with AFLP or HELLP should be screened for an inherited metabolic disorder.

 

If the fetus is found to be homozygous for a genetic defect, then the mother will be a heterozygous carrier.

 


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