Van der Veer et al reported the MastFx score to predict fragility fractures in patients with indolent systemic mastocytosis. Indolent systemic mastocytosis is associated with osteoporosis which may be complicated by fracture. The authors are from the University of Groningen in The Netherlands.
Patient selection: indolent systemic mastocytosis
Parameters:
(1) sex
(2) serum type I collagen C-telopeptide (sCTX) Z-score
(3) hip bone mineral density T score
(4) urticaria pigmentosa
(5) alcohol use
Parameter
Finding
Points
sex
female
0
male
1
sCTX Z score
>= 1
1
< 1
0
hip BMD T-scoer
<= -1
1
> -1
0
uritcaria pigmentosa
absent
1
present
0
alcohol use
no
0
yes
1
total score =
= SUM(points for all 5 parameters)
Interpretation:
• minimum score: 0
• maximum score: 5
Total Score
5-Year Fragility Fracture Rate
0 or 1
7%
2
22%
3
35%
4 or 5
86%
Performance:
• The area under the ROC curve is 0.80.
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