Chou et al reported the Marrow Metastases Prognostic Score (MMPS) for evaluation of a patient with metastases to the bone marrow. This is useful in making treatment decisions. The authors are from Chang Gung Memorial Hospital in Taiwan.
Patient selection: solid cancer with bone marrow metastases
Parameters:
(1) ECOG performance status
(2) site of primary cancer
(3) neutrophil-to-lymphocyte ratio (NLR)
(4) platelet count in 10^9/L
Parameter
Finding
Points
ECOG performance status
1
0
2
1.5
3
3
4
6
primary cancer site
prostate, breast or nasopharynx
0
other
2.5
NLR
< 4
0
>= 4
1
platelet count
> 100 * 10^9/L
0
50 to 100 * 10^9/L
1.5
< 50 * 10^9/L
2
total score =
= SUM(points for all 4 parameters)
Interpretation:
• minimum score: 0
• maximum score: 11.5
• The higher the score the worse the prognosis.
Score
Prognosis
Median Survival
0 to 4
good
241 to 305 days
4.5 to 7.5
intermediate
60 days
8 to 11.5
poor
10 days
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