The Malignant Syndrome in Parkinson's disease resembles the Neuroleptic Malignant Syndrome.
Patient selection: Parkinson's disease
Clinical features:
(1) high fever
(2) marked rigidity
(3) altered level of consciousness
(4) autonomic dysfunction
(5) elevated serum CK concentration
Risk factors:
(1) discontinuation of levodopa or other anti-Parkinsonian drugs
(2) battery depletion in deep brain stimulation
(3) infection
(4) dehydration
(5) hot weather
Complications:
(1) severe pneumonia
(2) DIC
(3) acute renal failure
