A patient with AIDS is at increased risk for developing a malignant lymphoproliferative disorder. A lymphoproliferative disorder thet develops in a patient with AIDS is likely to be high grade and aggressive.


Common lymphoproliferative disorders:

(1) immunoblastic lymphoma

(2) other diffuse large B-cell lymphoma

(3) Burkitt’s lymphoma


Less common disorders:

(1) Hodgkin’s disease

(2) T-cell chronic lymphocytic leukemia (CLL)


Rare disorders:

(1) primary effusion lymphoma (body cavity based lymphoma or BCBL)

(2) plasmablastic lymphoma associated with multi-centric Castleman’s disease

(3) plasmablastic lymphoma not associated with Castleman’s disease

(4) primary lymphoma of the brain


These tumors may show a variety lf genetic lesions including:

(1) Epstein-Barr virus (EBV)

(2) c-myc gene rearrangement

(3) bcl-6 gene rearrangement

(4) ras gene mutations

(5) p53 mutations or deletions


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