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Maintenance Dosage Fraction of an Antibiotic Based on the Fractional Rate Constant

Specialty:

Infectious Diseases
Clinical Pharmacology
Nephrology

Objective:

ICD-10:

Description:

If clearance data for renal failure is not available, then the fraction of the usual dose of drug required for patient with renal failure can be approximated by the ratio of the fractional rate constant for elimination from the body in renal failure to that with normal renal function. This ratio is then multiplied times the usual dose to get the dose needed in renal failure. Because the ratio gives the fraction of the usual dose to give for a degree of renal insufficiency, it is termed the dose fraction. The dose fraction (subscript 0) is the dose fraction when the creatinine clearance is 0.

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