Description

Most cases of fatty change involve macrovesicular deposits of triglycerides.


 

Features of macrovesicular steatosis:

(1) one or a few large vesicles that displace the hepatocyte nucleus

(2) may be mixed with microvesicular steatosis

 

Conditions associated with macrovesicular steatosis:

(1) obesity and the metabolic syndrome (nonalcoholic)

(2) alcohol

(3) drugs (acetaminophen, asparaginase, azidothymidine, cisplatin or oxaiplatin, clometacin, corticosteroids, dantrolene, etretinate, floxuridine, flurazepam, gold sodium thiomalate, halothane, ibuprofen, indomethacin, interferon, isoniazid, isotretinoin, methimazole, methotrexate, methyldopa, metoprolol, niacin, nitrofurantoin, rifampin, sulindac, tamoxifen)

 

The severity of steatosis is based on the percent of hepatocytes affected.

Percent of Hepatocytes Affected

Grade

Term

none

0

NA

1 to 29%

1

mild

30 to 60%

2

moderate

> 60%

3

severe

 


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