Lymphostatic warts (verrucosis) can develop in severe lymphedema. HPV is often associated with the lesions. One theory is that acquired immunodeficiency allows the virus to proliferate.
Clinical features of lymphostatic warts:
(1) severe lymphangiectasia
(2) verruciform skin lesions in the affected area
(3) lymphangiectasia associated with the verruciform lesions
(4) exclusion of other skin lesions
The combination of HPV-related warts, immunodeficiency and sun exposure may predispose the patient to cutaneous squamous cell carcinomas.
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