Lupus tumidus (lupus erythematosus tumidus) is a type of chronic cutaneous lupus erythematosus.
Risk factors:
(1) therapy with bortezomib
Clinical features of lupus tumidus:
(1) shiny, smooth, erythematous-violaceous urticarial plaque
(2) occurs in sun-exposed skin
(3) heals without scarring or hypopigmentation
(4) variable results for serum antinuclear antibodies (often negative or low-titer)
Histologic features:
(1) perivascular lymphocytic infiltrate in the dermis
(2) variable vacuolar degeneration of the basal membrane
(3) direct immunofluorescence at the epidermal-dermal junction is usually negative
The diagnosis requires exclusion of other diagnoses (reticular erythematous mucinosis, etc).
