Clinical presentation:
(1) cough
(2) dyspnea
(3) weight loss
(4) hemoptysis
Patterns of involvement:
(1) tracheobronchial (associated with smoking)
(2) nodular (associated with smoking, B-cell neoplasms and solid neoplasms)
(3) interstitial (associated with systemic amyloidosis)
(4) mixed pattern (associated with systemic amyloidosis)
Pulmonary amyloidosis may be limited to the lungs or may be part of multi-organ involvement.
About 60% of cases are related to light chain amyloidosis.
Sources of amyloidosis:
(1) multiple myeloma
(2) B-cell neoplasm
(3) solid neoplasm
(4) connective tissue disease
Risk factors for mortality:
(1) cardiac amyloidosis
(2) dyspnea at presentation
(3) older age (> 60 years of age)
Respiratory tract infection is a major cause of death.
