A low serum folic acid may contribute to erectile dysfunction.
Clinical features:
(1) presence of erectile dysfunction with or without premature ejaculation
(2) presence of folic acid deficiency
(3) improvement in sexual function with folic acid replacement
The severity of the erectile deficiency was greater for more severe folate deficiencies.
Mechanism: The deficiency may impact metabolism of nitric oxide, homocysteine and/or hydroxytryptamine.
A deficiency in folic acid may be present along with other factors affecting erectile dysfunction, which may make diagnosis and therapy more challenging.
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