Lofgren's syndrome is an acute form of sarcoidosis with a characteristic clinical presentation. It usually is associated with a good prognosis.
Classic diagnostic triad:
(1) erythema nodosum (red nodular lesions on the extremities)
(2) acute symmetrical periarticular swelling or polyarthritis, typically involving the ankles and feet
(3) bilateral hilar lymphadenopathy
Some authors also include:
(1) anterior uveitis
(2) unilateral hilar lymphadenopathy
The differential diagnosis of erythema nodosum and bilateral hilar adenopathy includes:
(1) malignant lymphoma
(2) tuberculosis
(3) deep fungal infection
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Specialty: Immunology/Rheumatology
ICD-10: ,
