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Classification for Liver Biopsy Findings in Patients Receiving Methotrexate Therapy

Purpose:

To evaluate a liver biopsy for changes associated with methotrexate hepatotoxicity using the Roenigk classification scheme.

Specialty:

Gastroenterology
Immunology/Rheumatology
Clinical Pharmacology & Toxicology

Objective:

severity, prognosis, stage, complications, options

ICD-10:

K71.9

Description:

Chronic methotrexate therapy may result in serious hepatotoxicity. Roenigk et al used a grading scheme to classify the severity of injury seen on liver biopsy. This can help determine how methotrexate therapy is to be continued.

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