McAfee et al listed a number of indications for when to perform a transjugular liver biopsy.


Major criteria:

(1) significant coagulation disorder (thrombocytopenia with platelet count < 60,000 per µL and/or prothrombin time more than 3 seconds above the upper limit of the normal reference range and/or severe hereditary bleeding disorder)

(2) moderate or severe ascites

(3) other reasons to place an intrahepatic vascular catheter (venous pressure measurement, portography, transjugular intrahepatic portosystemic shunt)


Minor criteria:

(1) morbid obesity

(2) small, cirrhotic liver

(3) suspected peliosis hepatis or vascular tumor


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