The liver biopsy in patients with hemochromatosis will show increased iron stores on histology, but quantitation of iron in the biopsy is the most accurate method for diagnosing hemochromatosis. Use of newer imaging technologies (CT scanning, measurement of magnetic susceptibility) can be used to assess a patient's iron stores. However, liver biopsy is still frequently performed since this allows evaluation for hepatic fibrosis and cirrhosis in addition to iron quantitation.

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